Why the study?
Differentiating Kawasaki disease and multisystem inflammatory syndrome in children is difficult, yet both can cause coronary aneurysms unless immunomodulatory treatment is initiated promptly.
Prompt immunomodulatory treatment should be initiated in infants presenting with features of Kawasaki disease or MIS-C to prevent coronary aneurysms, even before a definitive diagnosis is made.
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Diagnostic differentiation of KD and MIS-C remains challenging in infants with coronary aneurysms; leaves open refined classification criteria.
Key Clinical Message: COVID may manifest multisystem inflammatory syndrome in children (MIS-C) which mimics Kawasaki disease (KD). Differentiating KD and MIS-C is difficult. Immunomodulatory treatment should be initiated promptly without accurate diagnosis. Abstract: A febrile Ukrainian infant developed giant aneurysms in coronary arteries. Differentiating between Kawasaki disease and multisystem inflammatory syndrome in children was difficult. In both illnesses, coronary aneurysm may develop unless treated promptly. Therefore, guidelines should synthesize these clinical entities so that treatment can be initiated before rigorous diagnosis.
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Klymyshyn et al. (2023) studied this question.
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