Similarities and Differences between Coronavirus Disease 2019-related Multisystem Inflammatory Syndrome in Children and Kawasaki Disease in Indian Patients

prognosis is intricately linked to the extent and severity of cardiac involvement and the lasting alterations in the coronary arteries.KD poses a challenge due to its uncertain etiology, diverse clinical manifestations, and absence of definitive diagnostic tests.There is a suggestion that viral infections, including those involving other coronaviruses, may act as predisposing factors for KD. 9 This medium BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the emergence of coronavirus disease 2019 (COVID-19), which developed into a worldwide pandemic within 3 years.Most children infected with COVID-19 either show no symptoms or display mild ones.1,2 In April 2020, Italy reported an outbreak of a severe systemic inflammatory illness similar to Kawasaki disease (KD) in children.This condition was marked by frequent intensive care unit admissions due to cardiac impairment and shock.3 Following this, comparable instances surfaced in multiple nations, encompassing the United Kingdom, Spain, France, the United States of America, India, Brazil, and Korea.2,4 Presently, this ailment is acknowledged as a multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 or pediatric inflammatory multisystem syndrome (PIMS-Ts) temporarily linked to SARS-CoV-2.4-6 MIS-C commonly emerges 2-8 weeks following SARS-CoV-2 infection, characterized by significant complications involving infectious stimuli, systemic inflammation, and organ dysfunction.7 The primary indicators of MIS-C encompass fever, along with gastrointestinal, cardiac, and cutaneous manifestations, accompanied by hemodynamic alterations.Kawasaki disease (KD) is defined as an acute febrile condition that predominantly impacts young children.The most common complications of KD involve vasculitis and coronary arterial issues, which can contribute to an unfavorable long-term prognosis.8