Key result
COVID-19 MIS-C linked to ~177% higher prevalence of coronary artery dilation or aneurysms versus Kawasaki disease.
Why the study?
Geographical and racial factors constitute important distinctions between Kawasaki disease and MIS-C, but no study has been conducted in Vietnam.
Cohort (n=83)
No
Absolute Event Rate: 40.5% vs 14.6%
p-value: p=0.009
Children with COVID-19-related MIS-C in Vietnam presented with more frequent clinical symptoms and a significantly higher rate of coronary artery dilation compared to classic Kawasaki disease.
Supports closer coronary monitoring in MIS-C; leaves open differential mechanisms versus Kawasaki disease requiring prospective confirmation.
Geographical and racial factors constitute important distinctions between Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C), but no study has been conducted in Vietnam.Forty-one children with KD from January 2018 to July 2020 and 42 with KD/MIS-C from August 2020 to December 2022 were included in this study.Of the patients, 52.3% were aged between 12 and 35 months.Only two were aged over 5 years, and both were belong to the KD/MIS-C group.A 59.5% of the patients were male.Apart from fever, all symptoms tended to be more frequent in patients with KD/MIS-C.The prevalence of diffuse skin rash, hand and foot edema or erythema and gastrointestinal signs was significantly higher in patients hospitalized with KD/MIS-C.There was no significant difference in laboratory findings between the two groups.Coronary artery dilation was more frequently observed in patients with KD/MIS-C compared to those with KD (40.5% vs. 14.6%,P = 0.009).
No takes yet. Share an insight, caveat, or question.
Phi et al. (2023) conducted a cohort in Kawasaki Disease and COVID-19-Related Multisystem Inflammatory Syndrome in Children (MIS-C) (n=83). COVID-19-related Multisystem Inflammatory Syndrome in Children (KD/MIS-C) vs. Kawasaki Disease (KD) pre-COVID-19 was evaluated on Coronary artery dilation or aneurysm (p=0.009). Children with COVID-19-related multisystem inflammatory syndrome had a significantly higher prevalence of coronary artery dilation or aneurysm compared to those with Kawasaki disease (40.5% vs. 14.6%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: