March 1, 1999Artificial Organs

Major Organ Function Under Mechanical Support: Comparative Studies of Pulsatile and Nonpulsatile Circulation

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Why the study?

Does pulsatile mechanical circulatory support improve regional organ blood flow compared to nonpulsatile support in a pig model of acute myocardial infarction?

Population

Pig model of acute myocardial infarction

Comparison

Pulsatile biventricular assisted circulation for… vs Nonpulsatile biventricular assisted circulation…

Design

Preclinical

Follow-up

3 hours

Authors

ASAkira SezaiNihon University MSMotomi ShionoNihon University YOYukihiko OrimeNihon University

Discussion

Member takes

Implication

Pulsatile MCS may enhance renal and hepatic perfusion in acute HF models; hypothesis-generating for human trials, should not yet change practice.

Structured PICO

Does pulsatile mechanical circulatory support improve regional organ blood flow compared to nonpulsatile support in a pig model of acute myocardial infarction?

Population

Pig model of acute myocardial infarction

Intervention

Pulsatile biventricular assisted circulation (pulsatile pump for left ventricular circulation, nonpulsatile for right) for 3 hours

Comparator

Nonpulsatile biventricular assisted circulation (nonpulsatile pump for both left and right ventricular circulation) for 3 hours

Outcome

Regional blood flows of the cortex and medulla in the kidney, white matter and gray matter in brain, and liver; renal arterial flow; carotid arterial flow; portal vein flow; common hepatic arterial flow; arterial ketone body ratio (AKBR); and lactate/pyrubic acid (L/P)surrogate

Pulsatile mechanical circulatory support provides superior kidney and liver regional blood flow and microcirculation compared to nonpulsatile support in a preclinical model of acute heart failure.

Cite This Study

Sezai et al. (1999) studied this question.

synapsesocial.com/papers/6a91b77286d674eea9786354 https://doi.org/10.1046/j.1525-1594.1999.06318.x

Topics

Mechanical circulatory support

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Implication

Pulsatile MCS may enhance renal and hepatic perfusion in acute HF models; hypothesis-generating for human trials, should not yet change practice.

Major Organ Function Under Mechanical Support: Comparative Studies of Pulsatile and Nonpulsatile Circulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Major Organ Function Under Mechanical Support: Comparative Studies of Pulsatile and Nonpulsatile Circulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider