May 8, 2012PLoS ONEOpen Access

Subdomain Location of Mutations in Cardiac Actin Correlate with Type of Functional Change

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Population

Seven known human cardiac actin mutants associated with hypertrophic or dilated cardiomyopathy expressed in…

Comparison

Characterization of intrinsic properties of… vs Wild-type (WT) cardiac actin

Design

Preclinical

Authors

MMMaureen M. MundiaUniversity of Guelph RDRyan W. DemersAmorfix (Canada)MCMelissa ChowUniversity of South Florida

Discussion

Member takes

Implication

May refine ACTC cardiomyopathy models; leaves open human translation of subdomain effects.

Structured PICO

Population

Seven known human cardiac actin mutants associated with hypertrophic or dilated cardiomyopathy expressed in a baculovirus system

Intervention

Characterization of intrinsic properties of cardiac actin mutants (including R312H, L305M, E99K, Y166C)

Comparator

Wild-type (WT) cardiac actin

Outcome

Intrinsic properties of actin proteins including stability (Tm), polymerization critical concentration, Pi release rate, nucleotide release rates, and DNase-I inhibition abilitysurrogate

The subdomain location of mutations in cardiac actin correlates with specific functional changes, providing molecular insights into the development of cardiomyopathies.

Cite This Study

Mundia et al. (2012) studied this question.

synapsesocial.com/papers/6a91b85211b17c63ab5ce1d0 https://doi.org/10.1371/journal.pone.0036821

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Subdomain Location of Mutations in Cardiac Actin Correlate with Type of Functional Change

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Subdomain Location of Mutations in Cardiac Actin Correlate with Type of Functional Change

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider