Answers are grounded in this paper and cite their sources.
The amount of factor IX (Christmas factor) for different genotypic classes was determined by means of a variant of the thromboplastin generation test. The mean value for females heterozygous for the Christmas gene was about half the mean values for normal males and for normal homozygous females; means for the latter two groups were about equal. This dosage compensation is interpreted as evidence in support of Lyon's hypothesis, according to which one X chromosome is inactive in mammalian females.
No takes yet. Share an insight, caveat, or question.
Frota‐Pessoa et al. (1963) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: