Why the study?
Do high tumor tissue levels of TIMP-1 predict poor prognosis in patients with primary breast cancer?
Do high tumor tissue levels of TIMP-1 predict poor prognosis in patients with primary breast cancer?
High tumor tissue levels of TIMP-1 are associated with shorter recurrence-free and overall survival in patients with primary breast cancer, adding prognostic value to uPA and PAI-1.
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High TIMP-1 should not yet change practice in primary breast cancer; supports prospective validation of added prognostic value beyond uPA/PAI-1.
Schrohl et al. (2004) studied this question.
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