Why the study?
Does the combination of recombinant human alpha interferon and acyclovir improve survival in mice with lethal systemic herpes simplex virus type 1 infection compared to either agent alone?
Population
Weanling mice with a lethal systemic infection with herpes simplex virus type 1
Comparison
Combination of recombinant human alpha… vs Recombinant human alpha interferon alone or…
Design
Preclinical
Authors
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Does not support clinical HSV-1 use; leaves open translation of murine synergy to human trials.
Does the combination of recombinant human alpha interferon and acyclovir improve survival in mice with lethal systemic herpes simplex virus type 1 infection compared to either agent alone?
The combination of recombinant human alpha interferon and acyclovir shows synergistic activity in improving survival in a mouse model of lethal HSV-1 infection.
Connell et al. (1985) studied this question.
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