Why the study?
Is Borna disease virus (BDV) detectable in the serum or spinal fluid of patients with acute onset fibromyalgia?
Is Borna disease virus (BDV) detectable in the serum or spinal fluid of patients with acute onset fibromyalgia?
This study found no evidence of Borna disease virus infection in Danish patients with acute onset fibromyalgia, suggesting it is not a common etiology in this population.
Answers are grounded in this paper and cite their sources.
No BDV detected in acute FMS; leaves open its role in fibromyalgia and need for larger studies.
OBJECTIVE: The purpose of this study was to look for Borna disease virus (BDV) in 18 patients with acute onset of fibromyalgia (FMS) following a "flu-like" episode. BDV is a neurotropic RNA virus affecting horses and sheep. Infections in animals have been reported to cause immune mediated disease characterized by abnormalities in behavior. A possible link between BDV and neuropsychiatric diseases in man has been described, and lately a connection to chronic fatigue syndrome (CFS) has been suggested. METHODS: A BDV-specific nested PCR (RT-PCR) was performed on serum and spinal fluid. RESULTS: The BDV genome was not detected in any of the FMS cases. CONCLUSION: Although BDV was not demonstrated in spinal fluid or serum from the tested patients with FMS, we believe that it is important to report our results, since FMS can exhibit many manifestations in common with CFS. Possible reasons for the discrepant findings are discussed.
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Laurids Sii Irene Hechmann Wittrup (2000) studied this question.
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