Biosynthesis of anthracycline antibiotics by Streptomyces galilaeus. I. Glycosidation of various anthracyclinones by an aclacinomycin-negative mutant and biosynthesis of aclacinomycins from aklavinone.

Streptomyces galilaeus aclacinomycin-negative mutant strain KE303

Feeding of various anthracyclinones (epsilon- gamma- and beta-Rhodomycinones, epsilon-isorhodomycinone, epsilon- and beta-pyrromycinones, chemically modified aklavinones, daunomycinone, 13-deoxydaunomycinone, adriamycinone, steffimycinone)

Glycosidation to biologically active anthracyclinessurrogate