Why the study?
Does miglitol reduce myocardial infarct size in a rabbit model of ischemia-reperfusion?
Population
90 rabbits subjected to 30-min coronary occlusion followed by 48-h reperfusion or sacrificed at 30 min of…
Comparison
Miglitol administered pre-ischaemia or… vs Saline control
Design
Preclinical
Follow-up
48 hours
Authors
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Hypothesis-generating for miglitol in rabbit ischemia-reperfusion; clinical translation remains untested and should not change practice.
Does miglitol reduce myocardial infarct size in a rabbit model of ischemia-reperfusion?
Pre-ischemic administration of miglitol dose-dependently reduces myocardial infarct size in a rabbit model, likely by inhibiting glycogenolysis.
Minatoguchi et al. (1999) studied this question.
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