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Laboratory study demonstrates preservation of creatine phosphate and intracellular pH during sustained ischemia, indicating pH stability strongly limits infarct size.
In addition to ATP and ultrastructure, preconditioning preserved CP and pHi during sustained ischemia. These protective effects might be due to overshoot phenomenon of CP and/or reduced ATP consumption. The relatively longer period of preservation of pHi, which probably is the result of reduced ATP consumption, indicates its greater contribution to reducing infarct size than that of CP and ATP.
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Kida et al. (1991) studied this question.
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