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January 1, 2001Journal of the Chemical Society Perkin Transactions 2

Gadolinium DO3A derivatives mimicking phospholipids; preparation and in vitro evaluation as pH responsive MRI contrast agents

Ragnar Hovland Christian Gløgård Arne J. Aasen Jo Klaveness

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Abstract

A series of Gd-DO3A derivatives (8a–d) mimicking phospholipids have been prepared. Two of the complexes, Gd-HADB-DO3A (8a) and Gd-HADO-DO3A (8b), have been evaluated as pH responsive MRI contrast agents in vitro. The T1-relaxivity (r1) of Gd-HADO-DO3A (8b) increased 142% on changing the pH from 6 to 8. The pH dependence is thought to arise from the formation of supramolecular structures caused by deprotonation of the amphiphilic complex at alkaline pH.

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Hovland et al. (2001) studied this question.

synapsesocial.com/papers/6a923190fd48e269e6b88131 https://doi.org/10.1039/b100405k

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