In Treating Infertility, Are Multiple Pregnancies Unavoidable?

The demand for high rates of pregnancy among women treated for infertility has encouraged a tacit acceptance of certain complications of the treatment. This is especially true when treatment results in multiple gestation, and indeed, twins are often perceived as a desired outcome. The first large study to highlight this problem in the context of superovulation treatment was conducted by Guzick and colleagues,1 who found that superovulation was associated with a 20 percent incidence of pregnancy with twins and a nearly 10 percent incidence of higher-order multiple pregnancy. These results were similar to those obtained from a systematic review of . . .