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BACKGROUND: Self-renewal of gastric cancer stem cells (GCSCs) is considered to be the underlying cause of the metastasis, drug resistance, and recurrence of gastric cancer (GC). AIM: To characterize the expression of stem cell-related genes in GC. METHODS: RNA sequencing results and clinical data for gastric adenoma and adenocarcinoma samples were obtained from The Cancer Genome Atlas database, and the results of the GC mRNA expression-based stemness index (mRNAsi) were analyzed. Weighted gene coexpression network analysis was then used to find modules of interest and their key genes. Survival analysis of key genes was performed using the online tool Kaplan-Meier Plotter, and the online database Oncomine was used to assess the expression of key genes in GC. RESULTS: ) were consistently related. CONCLUSION: are the most likely therapeutic targets for inhibiting the stemness characteristics of GC cells.
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Huang et al. (2020) studied this question.
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