What question did this study set out to answer?

To review the biological properties of cancer stem cells—particularly quiescence and plasticity—and evaluate how these traits drive treatment resistance and influence therapeutic design.

January 1, 2016Stem Cells InternationalOpen Access

Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy

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Authors

WCWanyin ChenJiangsu University JDJihu DongCentre National de la Recherche Scientifique JHJacques HaiechCité des Sciences et de l'Industrie

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Implication

Narrative review reveals mechanisms of cancer stem cell quiescence and plasticity across malignancies, highlighting key therapeutic targets to overcome treatment resistance.

Key Points

To review the biological properties of cancer stem cells—particularly quiescence and plasticity—and evaluate how these traits drive treatment resistance and influence therapeutic design.
Synthesized evidence on the identification, isolation, and functional characterization of cancer stem cells across diverse human malignancies.
Evaluated emerging molecular targets, microenvironmental interactions, and clinical limitations associated with existing anti-cancer stem cell strategies.
Identified relative in vivo quiescence as a central survival mechanism that shields cancer stem cell subpopulations from antiproliferative therapies.
Highlighted microenvironment-driven cellular plasticity as a key factor enabling cancer stem cells to dynamically alter their phenotypes under therapeutic stress.
Determined that overcoming treatment failure requires novel multi-target strategies capable of eliminating both dormant and plastic tumor-initiating cells.

Cite This Study

Chen et al. (2016) studied this question.

synapsesocial.com/papers/6a7b376e8d250a4360f457e9 https://doi.org/10.1155/2016/1740936

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Implication

Narrative review reveals mechanisms of cancer stem cell quiescence and plasticity across malignancies, highlighting key therapeutic targets to overcome treatment resistance.

Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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