What question did this study set out to answer?

To review the biological characteristics and mechanisms that allow cancer stem cells to resist drugs and to assess novel therapeutic strategies designed to eliminate them.

January 1, 2018Stem Cells InternationalOpen Access

Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment

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Authors

LPLan Thi PhiVietnam National University Ho Chi Minh City ISIta Novita SariAgency for Science, Technology and Research YYYinggui YangSouthern Medical University Shenzhen Hospital

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Implication

Narrative review uncovers mechanisms of cancer stem cell drug resistance, highlighting emerging targeted therapeutic approaches to prevent relapse.

Key Points

To review the biological characteristics and mechanisms that allow cancer stem cells to resist drugs and to assess novel therapeutic strategies designed to eliminate them.
Synthesized molecular and cellular mechanisms governing cancer stem cell self-renewal and lineage differentiation.
Evaluated preclinical and clinical breakthroughs in targeted therapies aimed at eradicating tumor-initiating cells.
Cancer stem cells mediate therapeutic failure and disease recurrence through sustained self-renewal capacity and differentiation into heterogeneous lineages.
Novel anticancer therapeutic strategies directly targeting cancer stem cell pathways offer promising avenues to overcome drug resistance.

Cite This Study

Phi et al. (2018) studied this question.

synapsesocial.com/papers/69ffeacb6be84a7ac8855c08 https://doi.org/10.1155/2018/5416923

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Implication

Narrative review uncovers mechanisms of cancer stem cell drug resistance, highlighting emerging targeted therapeutic approaches to prevent relapse.

Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment

Discussion

Member takes

Implication

Key Points

Cite This Study

Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment

Discussion

Member takes

Implication

Key Points

Cite This Study

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