Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 12, 2026Journal of Hematology & OncologyOpen Access

Cancer stem cell plasticity: mechanisms, immune microenvironment crosstalk, and therapeutic implications

View Full Paper
Ask AI
Bookmark
Share

Authors

JTJingyu TanTWTao WenJLJ S Liu

Discussion

Loading...

Member takes

Overview

This review highlights mechanisms of cancer stem cell plasticity in relation to the immune environment, suggesting therapeutic strategies.

Key Points

  • This review explores the mechanisms behind cancer stem cell plasticity and its interaction with the immune microenvironment.
  • Summary of recent advances in cancer stem cell plasticity research.
  • Analysis of the interplay between cancer stem cells and immune microenvironment.
  • Discussion of strategies targeting cancer stem cell plasticity and associated challenges.
  • Cancer stem cell plasticity is maintained through stemness signaling pathways such as Wnt, Notch, and Hedgehog.
  • Metabolic reprogramming supports cancer stem cell survival under therapeutic and immune pressures.
  • Combination strategies targeting cancer stem cell plasticity demonstrate potential but require clinical validation.

Cite This Study

Tan et al. (2026) studied this question.

synapsesocial.com/papers/6a532ed74f7abc118adecc8ahttps://doi.org/10.1186/s13045-026-01828-0
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The metabolic plasticity of cancer stem cells: bidirectional crosstalk with organ-resident cells2026 · 1 citations
  2. 2Cancer stem cells in personalized therapy: mechanisms, microenvironment crosstalk, and therapeutic vulnerabilities2025 · 16 citations
  3. 3Cancer stem cells and drug resistance in cancer: molecular mechanisms and therapeutic targets2026
  4. 4Cancer stem cells in focus: Deciphering the dynamic functional landscape of stemness in cancer2025 · 11 citations
  5. 5Targeting the Achilles’ heel of cancer stem cells2026