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June 11, 2026Experimental & Molecular MedicineOpen Access

The metabolic plasticity of cancer stem cells: bidirectional crosstalk with organ-resident cells

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Authors

JJJunseok JangMGMinseo GwakHKHyunggee Kim

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Overview

This Review examines how cancer stem cells' metabolism interacts with their surrounding environment, suggesting new treatment strategies.

Key Points

  • The aim is to understand how the tumor microenvironment influences metabolic states in cancer stem cells.
  • Synthesized insights from various studies on cancer stem cells and their interactions with organ-resident cells.
  • Discussed the role of stromal and parenchymal cells in shaping CSC metabolic niches.
  • Explored drug repurposing strategies to target metabolic adaptations in CSCs.
  • Cancer stem cells exhibit metabolic plasticity influenced by the tumor microenvironment's diverse cell populations.
  • Bidirectional crosstalk between CSCs and surrounding cells enhances stemness and resistance to therapies.
  • Targeting metabolic niches could provide new avenues for overcoming treatment resistance in CSCs.

Cite This Study

Jang et al. (2026) studied this question.

synapsesocial.com/papers/6a2a520a80c8f91e7f39e267https://doi.org/10.1038/s12276-026-01746-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The metabolic profiles of cancer stem cells2026
  2. 2Cancer stem cells: landscape, challenges and emerging therapeutic innovations2025 · 180 citations
  3. 3Cancer stem cell plasticity: mechanisms, immune microenvironment crosstalk, and therapeutic implications2026
  4. 4Targeting Glycolytic Plasticity to Overcome Therapy Resistance in Cancer Stem Cells: Mechanisms and Clinical Perspectives2026
  5. 5Metabolic Plasticity and Cancer Stem Cell Metabolism: Exploring the Glycolysis-OXPHOS Switch as a Mechanism for Resistance and Tumorigenesis2025 · 55 citations