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June 20, 2026CellsOpen Access

Targeting Glycolytic Plasticity to Overcome Therapy Resistance in Cancer Stem Cells: Mechanisms and Clinical Perspectives

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Authors

JHJ Z HuangXYXinyu YangFLFeiyu Li

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Overview

Review delineates metabolic shifts affecting resistance in cancer stem cells, suggesting new therapeutic strategies.

Key Points

  • The aim is to understand how metabolic plasticity in cancer stem cells drives therapy resistance.
  • Review of existing literature on cancer stem cell metabolism and therapeutic interventions.
  • Analysis of regulatory mechanisms controlling metabolic shifts in cancer stem cells.
  • Evaluation of emerging therapeutic strategies targeting metabolic vulnerabilities.
  • Glycolytic adaptation is a key driver of therapy resistance in cancer stem cells.
  • Regulatory mechanisms include enzymes, epigenetic changes, and transcription factors.
  • Emerging strategies like small-molecule inhibitors and immunometabolic regimens show promise.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a3631fbdb0793dc1a538ad2https://doi.org/10.3390/cells15121107
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolic Plasticity and Cancer Stem Cell Metabolism: Exploring the Glycolysis-OXPHOS Switch as a Mechanism for Resistance and Tumorigenesis2025 · 55 citations
  2. 2Cancer stem cells: landscape, challenges and emerging therapeutic innovations2025 · 180 citations
  3. 3The metabolic profiles of cancer stem cells2026
  4. 4The metabolic plasticity of cancer stem cells: bidirectional crosstalk with organ-resident cells2026 · 1 citations
  5. 5Cancer stem cells and drug resistance in cancer: molecular mechanisms and therapeutic targets2026