This preclinical study highlights significant species-specific differences in the functional autonomic innervation of the cardiac pacemaker during the perinatal period.
Species differences urge caution extrapolating perinatal cardiac innervation data to humans; leaves open optimal translational models for autonomic maturation.
Sinoatrial node pacemaker tissues from perinatal and adult rabbits, guinea pigs and rats were examined in vitro. Changes in spontaneous pacemaker rate produced by stimulation of intranodal vagal and sympathetic nerve endings, were taken as a measure of functional postganglionic innervation of the pacemaker. Results show marked species differences in the development of functional innervation of the cardiac pacemaker in the perinatal period.
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Vlk et al. (2009) studied this question.
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