Population
52 puppies, 1 to 6 weeks of age
Design
Preclinical
Follow-up
up to 6 weeks of age
Authors
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Hypothesis-generating for developmental sympathetic imbalance in neonatal arrhythmias; leaves open translation to human pediatric electrophysiology.
Functional sympathetic innervation of the heart develops irregularly over the first 6 weeks of life in dogs, which may provide a basis for regional sympathetic imbalance and arrhythmogenesis in early life.
Kralios et al. (1978) studied this question.
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