The developed 51Chromium release micro-assay provides an objective, highly reproducible method to measure specific lymphocyte and antibody cytotoxicity to tumor cells within 6 hours.
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Animal data indicate virus-specific antitumor cytotoxicity; leaves open translation to human viral cancers or therapies.
51Chromim release micro-assays for both lymphocyte and antibody cytotoxicity have been developed. Tests vs. several different types of target cells can be performed on 1 to 5 ml of blood. The results are objective, highly reproducible and can be obtained within 6 hrs. Application of this test system to primates carrying tumors induced by various oncornaviruses has Shown highly specific responses i.e. the animals developed lymphocyte and antibody cytotoxicity against cells transformed by the same virus which had induced their tumors but they remained non-reactive against cells transformed by other viruses.
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Johnson et al. (1972) studied this question.
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