What question did this study set out to answer?

To determine how dietary docosahexaenoic acid affects the in vivo absorption, clearance, and desaturation pathways of isotope-labeled oleic, linoleic, and linolenic acids in humans.

August 1, 1999Lipids

Effect of dietary docosahexaenoic acid on desaturation and uptake in vivo of isotope‐labeled oleic, linoleic, and linolenic acids by male subjects

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Authors

EEE. A. EmkenNorthern Illinois University RAR. O. AdlofNorthern Illinois University SDSandra M. DuvalNational Center for Agricultural Utilization Research

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Implication

Metabolic trial reveals high dietary docosahexaenoic acid suppresses synthesis of long-chain fatty acid metabolites in men, suggesting benefits stem from reduced accumulation of omega-6 metabolites.

Key Points

To determine how dietary docosahexaenoic acid affects the in vivo absorption, clearance, and desaturation pathways of isotope-labeled oleic, linoleic, and linolenic acids in humans.
Six male subjects (n = 6) housed in a metabolic unit were fed diets containing either 6.5 g/d (HI-DHA) or <0.1 g/d (LO-DHA) of docosahexaenoic acid for 90 days.
Subjects ingested deuterated triglycerides (18:1n-9[d6], 18:2n-6[d2], and 18:3n-3[d4]), and blood samples collected up to 72 hours post-dose were analyzed using gas chromatography-mass spectrometry.
High-DHA diet decreased the accumulation of n-3 long-chain fatty acid metabolites 20:5n-3[d4] by 76% and 22:6n-3[d4] by 88%, and suppressed n-6 metabolites 20:3n-6[d2] and 20:4n-6[d2] each by 72%.
Absorption of labeled fatty acids into chylomicron triglycerides was unaffected by diet, clearance was modestly elevated in the HI-DHA group, and no diet effect occurred on acyltransferase selectivity.
DHA supplementation at 6.5 g/d is estimated to lower endogenous synthesis of n-3 metabolites from ~120 to 30 mg/d and n-6 metabolites from ~800 to 180 mg/d.

Cite This Study

Emken et al. (1999) studied this question.

synapsesocial.com/papers/6a9239fd32c5e70179c800b8 https://doi.org/10.1007/s11745-999-0424-2

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Implication

Metabolic trial reveals high dietary docosahexaenoic acid suppresses synthesis of long-chain fatty acid metabolites in men, suggesting benefits stem from reduced accumulation of omega-6 metabolites.

Effect of dietary docosahexaenoic acid on desaturation and uptake in vivo of isotope‐labeled oleic, linoleic, and linolenic acids by male subjects

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of dietary docosahexaenoic acid on desaturation and uptake in vivo of isotope‐labeled oleic, linoleic, and linolenic acids by male subjects

Discussion

Member takes

Implication

Key Points

Cite This Study

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