December 1, 1993Circulation ResearchOpen Access

Differences in cardioprotective efficacy of adrenergic receptor antagonists and Ca2+ channel antagonists in an animal model of dilated cardiomyopathy. Effects on gross morphology, global cardiac function, and twitch force.

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Why the study?

Do adrenergic receptor antagonists and Ca2+ channel antagonists prevent dilatation and improve contractile performance in a turkey model of dilated cardiomyopathy?

Population

Turkey poults fed furazolidone in high concentrations to develop dilated cardiomyopathy

Comparison

Chronic administration of a beta 1-selective… vs Control animals and Fz-DCM animals

Design

Preclinical

Authors

MGMariel GlassHarvard University FFFarid J. D. FuleihanBoston Biomedical Research Institute RLRonglih LiaoHeart Failure & Transplant

Discussion

Member takes

Implication

Propranolol and nifedipine merit testing in additional DCM models; leaves open translation from this avian study to human disease.

Structured PICO

Do adrenergic receptor antagonists and Ca2+ channel antagonists prevent dilatation and improve contractile performance in a turkey model of dilated cardiomyopathy?

Population

Turkey poults fed furazolidone (Fz) in high concentrations (700 ppm) to develop dilated cardiomyopathy (Fz-DCM)

Intervention

Chronic administration of a beta 1-selective antagonist (atenolol), a nonselective beta-receptor antagonist (propranolol), an alpha-receptor antagonist (phenoxybenzamine), or two Ca2+ channel antagonists (nifedipine, verapamil) in the presence of Fz administration

Comparator

Control animals (no Fz, no pharmacologic agent) and Fz-DCM animals (Fz alone)

Outcome

Cardioprotection (prevention of dilatation and wall thinning, and improvement in contractile performance)surrogate

In a turkey model of dilated cardiomyopathy, nonselective beta-blockade (propranolol) and calcium channel blockade (nifedipine) provided superior cardioprotection compared to selective beta-blockade, verapamil, or alpha-blockade.

Cite This Study

Glass et al. (1993) studied this question.

synapsesocial.com/papers/6a923bf1fd03cddea1962bda https://doi.org/10.1161/01.res.73.6.1077

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Differences in cardioprotective efficacy of adrenergic receptor antagonists and Ca2+ channel antagonists in an animal model of dilated cardiomyopathy. Effects on gross morphology, global cardiac function, and twitch force.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differences in cardioprotective efficacy of adrenergic receptor antagonists and Ca2+ channel antagonists in an animal model of dilated cardiomyopathy. Effects on gross morphology, global cardiac function, and twitch force.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider