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March 1, 1988Annals of the New York Academy of Sciences

Antagonists and Activators at Calcium Channels

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Population

Gastrointestinal and cardiovascular smooth muscle voltage-dependent calcium channels

Design

Review

Authors

MSMichael SpeddingTa Solutions (China)

Discussion

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Implication

Should not alter calcium antagonist use in GI disorders; leaves open acyl carnitines as endogenous regulators for targeted study.

Structured PICO

P
Population
Gastrointestinal and cardiovascular smooth muscle voltage-dependent calcium channels
I
Intervention
Calcium antagonists and activators

This review highlights the similarities between gastrointestinal and cardiovascular voltage-dependent calcium channels and suggests acyl carnitines as potential endogenous activators.

Cite This Study

Michael Spedding (1988) studied this question.

synapsesocial.com/papers/6a923bf1fd03cddea1962be2https://doi.org/10.1111/j.1749-6632.1988.tb33362.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Verapamil on Gastric Secretion in Man1983 · 20 citations
  2. 2Differences Between the Effects of Calcium Antagonists in the Pithed Rat Preparation1982 · 22 citations
  3. 3Intracellular electrical activity of canine and human gastric smooth muscle.1978 · 176 citations
  4. 4Direct activation of Ca<sup>2+</sup> channels by palmitoyl carnitine, a putative endogenous ligand1987 · 73 citations