September 1, 1997Neurology

Cardiac cephalgia: A treatable form of exertional headache

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Why the study?

Do resting-state fMRI alterations in Anorexia nervosa normalize with treatment and recovery independently of grey matter volume?

Structured PICO

Do resting-state fMRI alterations in Anorexia nervosa normalize with treatment and recovery independently of grey matter volume?

Population

87 female subjects: adolescent patients with acute Anorexia nervosa (AN) scanned at inpatient admission (N = 22, mean age 15.3 years) and at discharge (N = 21), 21 patients recovered from AN (mean age 22.3 years), and two groups of healthy age-matched controls (both N = 22, mean ages 16.0 and 22.5 years).

Intervention

Treatment for Anorexia nervosa (longitudinal assessment from admission to discharge) and long-term recovery

Comparator

Healthy age-matched controls

Outcome

Whole-brain measures of resting-state activity and functional connectivity (Network Based Statistics, Global Correlation, Integrated Local Correlation, fractional Amplitude of Low Frequency Fluctuations) before and after controlling for underlying grey matter volumesurrogate

Resting-state fMRI alterations in Anorexia nervosa are acute, starvation-related phenomena that normalize with recovery independently of grey matter volume changes.

Discussion

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Implication

rs-fMRI changes in acute AN appear reversible with recovery independent of GMV; hypothesis-generating for monitoring treatment response.

Cite This Study

Lipton et al. (1997) studied this question.

synapsesocial.com/papers/6a923c000e9b60bc4641e081 https://doi.org/10.1212/wnl.49.3.813

View Full Paper

Ask AI

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Cardiac cephalgia: A treatable form of exertional headache

Structured PICO

Discussion

Implication

Cite This Study

Cardiac cephalgia: A treatable form of exertional headache

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider