What question did this study set out to answer?

To determine the relative importance of neural versus pituitary actions of estradiol in triggering the preovulatory luteinizing hormone surge in ewes.

April 2, 2008Neuroendocrinology

Importance of Pituitary and Neural Actions of Estradiol in Induction of the Luteinizing Hormone Surge in the Ewe

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To determine the relative importance of neural versus pituitary actions of estradiol in triggering the preovulatory luteinizing hormone surge in ewes.
Used an ovariectomized, progesterone-implanted anestrous ewe model to eliminate endogenous pulsatile GnRH and ovarian steroid secretion.
Administered controlled GnRH pulses via infusion pumps and estradiol via implants across two experiments to test abrupt versus progressive increases and varied baseline estradiol concentrations.
Abrupt increases in estradiol and GnRH pulse frequency produced an LH surge in all ewes, whereas progressive increases to identical levels failed to do so unless followed by a sudden supplementary GnRH increase.
Standard surge-inducing GnRH pulse patterns elicited full-amplitude LH surges only in the presence of peak estradiol levels, failing under conditions of basal or absent estradiol.

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Implication

Controlled experimental study demonstrates dual neural and pituitary estradiol actions trigger the luteinizing hormone surge in ewes, indicating coordinated central and glandular control.

Cite This Study

Kaynard et al. (2008) studied this question.

synapsesocial.com/papers/6a923d327506acb8fd5eebc0 https://doi.org/10.1159/000125025

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Implication

Controlled experimental study demonstrates dual neural and pituitary estradiol actions trigger the luteinizing hormone surge in ewes, indicating coordinated central and glandular control.

Importance of Pituitary and Neural Actions of Estradiol in Induction of the Luteinizing Hormone Surge in the Ewe

Key Points

Discussion

Implication

Cite This Study

Importance of Pituitary and Neural Actions of Estradiol in Induction of the Luteinizing Hormone Surge in the Ewe

Key Points

Discussion

Implication

Cite This Study

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