Total Synthesis of Kaempferol and Methylated Kaempferol Derivatives

Kaempferol (1), a natural product from various plants, was synthesized in which the longest linear sequence is only seven steps in over all yields of 47% from commercially avail able 1,3,5‐trimethoxybenzene (10). The methylated kaempferols 2–5 were also pre pared by use of this concise synthetic methodology. The key transformations in this synthesis involved the I2 oxidative‐promoting‐cyclization and DDO oxidative hydroxylation. Several strategies to achieve 1 are provided.