Why the study?
It was unknown whether baseline neutrophil counts affect the risk of new-onset proteinuria in hypertensive patients and whether folic acid treatment is particularly effective in preventing proteinuria in this setting.
Does folic acid added to enalapril reduce new-onset proteinuria in hypertensive patients?
Population
8208 hypertensive participants without baseline proteinuria from the CSPPT renal substudy
Comparison
Enalapril 10 mg plus folic acid 0.8 mg daily vs enalapril 10 mg daily
Design
Double-blind randomized trial substudy
Follow-up
Median 4.4 years
Authors
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Folic acid added to enalapril reduces proteinuria risk in hypertensives with high neutrophils; extends CSPPT findings via significant treatment interaction.
Does folic acid added to enalapril reduce new-onset proteinuria in hypertensive patients?
Folic acid supplementation added to enalapril significantly reduces the risk of new-onset proteinuria in hypertensive patients with elevated baseline neutrophil counts.
Zhang et al. (2020) studied this question.
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