Why the study?
Weight regain affects approximately 30% of patients post-bariatric surgery and relates to recurrence of medical problems, but whether body composition and metabolic biomarkers return to pre-operative levels remained to be tested.
Does weight regain after sleeve gastrectomy reverse improvements in body composition and metabolic biomarkers compared to sustained weight loss or pre-operative obesity?
Does weight regain after sleeve gastrectomy reverse improvements in body composition and metabolic biomarkers compared to sustained weight loss or pre-operative obesity?
Weight regain after sleeve gastrectomy is associated with a complete reversal of surgery-induced improvements in body composition and metabolic biomarkers, returning them to pre-operative obesity levels.
Answers are grounded in this paper and cite their sources.
WR may warrant biomarker monitoring post-bariatric surgery; cross-sectional data leaves open causal dynamics and intervention effects.
INTRODUCTION: Weight regain (WR) is described in approximately 30% of patient's post-bariatric surgery. It is related to the progression or recurrence of associated medical problems and decline in health-related quality of life. This study aimed to test the return of body composition and metabolic biomarkers to pre-operative levels when WR occurs. METHODS: In this cross-sectional study conducted in 2021, patients were randomly selected from the hospital's electronic databases between 2001 and 2020. Patient demographic data, comorbidities, body compositions, and metabolic biomarkers were collected. Three groups were defined: groups A (WR), B (weight loss), and C (control group; patients with obesity who had not yet undergone bariatric surgery). RESULTS: ; group B was 28.6 ± 4.2; group C was 43.9 ± 7.1. Body muscle mass, body fat mass, and visceral fat significantly differed between groups A and B (p < 0.001) but not between groups A and C (p = 0.8). There was a significant difference in leptin, ghrelin, postprandial glucagon-like peptide-1, insulin, and fibroblast growth factor-21 (but not retinol-binding protein-4) between groups A and B. Most metabolic biomarkers in group A returned to the pre-operative values as in group C. CONCLUSION: WR had a direct negative effect on body composition and metabolic biomarkers, whereby the values returned to pre-operative levels. Early detection of WR and possible additional therapy are necessary to prevent associated medical problems.
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Hany et al. (2022) studied this question.
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