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December 3, 2022Obesity SurgeryOpen Access

Effect of Weight Regain on Body Composition and Metabolic Biomarkers After Sleeve Gastrectomy: a Cross-Sectional Study from a Hospital Database

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Why the study?

Weight regain affects approximately 30% of patients post-bariatric surgery and relates to recurrence of medical problems, but whether body composition and metabolic biomarkers return to pre-operative levels remained to be tested.

Does weight regain after sleeve gastrectomy reverse improvements in body composition and metabolic biomarkers compared to sustained weight loss or pre-operative obesity?

Population

Patients randomly selected from a hospital database between 2001 and 2020

Comparison

Weight regain vs weight loss after sleeve gastrectomy vs non-surgical obesity controls

Design

Cross-sectional study

Authors

MHMohamed HanyHDHala Mourad DemerdashAZAhmed Zidan

Discussion

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Member takes

Overview

WR may warrant biomarker monitoring post-bariatric surgery; cross-sectional data leaves open causal dynamics and intervention effects.

Structured PICO

Does weight regain after sleeve gastrectomy reverse improvements in body composition and metabolic biomarkers compared to sustained weight loss or pre-operative obesity?

P
Population
Patients selected from a hospital electronic database (2001-2020) divided into three groups: post-sleeve gastrectomy with weight regain (Group A), post-sleeve gastrectomy with weight loss (Group B), and patients with obesity who had not yet undergone bariatric surgery (Group C).
I
Intervention
Weight regain after sleeve gastrectomy (Group A)
C
Comparator
Sustained weight loss after sleeve gastrectomy (Group B) and pre-operative obesity without bariatric surgery (Group C)
O
Outcome
Body composition (body muscle mass, body fat mass, visceral fat) and metabolic biomarkers (leptin, ghrelin, postprandial glucagon-like peptide-1, insulin, fibroblast growth factor-21, retinol-binding protein-4)surrogate

Weight regain after sleeve gastrectomy is associated with a complete reversal of surgery-induced improvements in body composition and metabolic biomarkers, returning them to pre-operative obesity levels.

Cite This Study

Hany et al. (2022) studied this question.

synapsesocial.com/papers/6a924fb89d072e6712f0cb4ehttps://doi.org/10.1007/s11695-022-06384-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Microvascular Function, Inflammatory Status, and Oxidative Stress in Post-Bariatric Patients with Weight Regain2023 · 1 citations
  2. 2Ten-Year Weight Regain After Bariatric Surgery: Prevalence, Predictors, and Metabolic Impact2025
  3. 3WEIGHT REGAIN AND THE METABOLIC PROFILE OF WOMEN IN THE POSTOPERATIVE PERIOD OF BARIATRIC SURGERY: A MULTIVARIATE ANALYSIS2023 · 9 citations
  4. 4IBC Oxford Poster Abstract 13 - Definition and predictors of weight regain after metabolic bariatric surgery: a systematic review and meta-analysis2026
  5. 5A cross-sectional survey of patients attending follow-up visits after sleeve gastrectomy: Factors affecting weight loss2022 · 1 citations