Why the study?
Striated muscle contraction can be perturbed by pathological conditions, physiological adaptations, and pharmacological interventions, creating a need for a methodology to robustly determine perturbation mechanisms and statistically evaluate their effects.
Design
Computational tool development and validation study
Authors
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Methodology for evaluating contraction perturbations may advance mechanistic research; leaves open clinical validation and adoption.
A newly developed computational tool provides a robust methodology to study the mechanisms of muscle diseases and therapeutic interventions targeting muscle contraction.
Barrick et al. (2019) studied this question.
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