Population
Skinned muscle fibers labeled with maleimide spin-label at Cys-707 of myosin
Comparison
Aluminum fluoride, Ca, and ATP to trap… vs Relaxed fibers
Design
Preclinical
Authors
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No clinical implications yet; leaves open whether restricted myosin head dynamics drive force generation in intact muscle.
The study provides biophysical evidence that strongly attached myosin heads in a pre-power stroke state have restricted microsecond dynamics, supporting the hypothesis that head ordering drives force generation.
Raucher et al. (1994) studied this question.
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