A Double-Blind Comparative Study of the Tolerance of Sodium and Meglumine Ioxaglate (Hexabrix) with Meglumine Iothalamate (Conray) in Ascending Phlebography of the Leg

100 patients were examined by ascending phlebography of both legs in a prospective, double-blind within patient study. Each leg was randomly allocated to the examination using either Hexabrix 320 or Conray 280 as the contrast medium, Immediate side effects were recorded in all patients, and delayed effects in 55 patients. Statistical analysis using the Chi-squared test showed that Hexabrix 320 produced significantly less immediate and delayed pain in the foot and/or leg than Conray 280. Hexabrix also produced significantly less delayed swelling than Conray. The authors conclude that the low osmolality medium Hexabrix 320 represents a significant advance in patient tolerance for ascending phlebography of the legs.