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A study was undertaken to attempt to quantify the alleged inhibitory effect of the serum of cancer patients on in-vitro lymphocyte transformation. The sera of ten cancer patients, ten patients with non-neoplastic diseases, and ten healthy controls were separately tested in short-term tissue cultures of donor lymphocytes. All cultures were grown in triplicate and repeated on three different occasions. Lymphocyte transformation was measured by radioactive thymidine uptake. There was no significant difference between the lymphocyte transformation occurring in the presence of the serum of cancer patients and of that found in the serum of healthy controls. Under the conditions of this study, we have been unable to confirm the presence of a decreased response to phytohemagglutinin by normal lymphocytes grown in cultures with sera of cancer patients.
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Golob et al. (1969) studied this question.
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