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The passive permeability of synaptosomes to ions was measured by a light‐scattering technique. Synaptosomes were freely permeable to acetate, HCO3_, SCN−and NH4+ and were impermeable to choline and SO42‐. Gramicidin D selectively increased the permeability of synaptosomes to Na+ and K+ ions. The relative permeabilities of Na+, K+ and Cl−, measured in the presence of a number of more permeant counter‐ions, was in the ratio 1:19:12. These values are discussed in terms of the source of the resting potential.
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Keen et al. (1971) studied this question.
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