Enantiomerically Pure Tertiary Alcohols by TADDOL‐Assisted Additions to Ketones—or How to Make a Grignard Reagent Enantioselective

Nucleophilic additions to ketones with CC bond formation which selectively produce tertiary stereogenic carbon centers are rare. The authors succeeded in preparing enantioselective Grignard reagents with TADDOL (1), which react with methyl ketones, affording tertiary alcohols with enantiopurities of up to 98% ee (1, Aryl = phenyl, 2-naphthyl).