What question did this study set out to answer?

To evaluate cardiovascular parameter responses to incremental infusions of dobutamine in healthy conscious dogs using standardized dobutamine stress echocardiography.

September 1, 1998American Journal of Veterinary ResearchOpen Access

Physiologic response to dobutamine infusion during cardiac stress testing of dogs

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Why the study?

Does dobutamine infusion alter cardiovascular variables during stress echocardiography in healthy dogs?

Key Points

To evaluate cardiovascular parameter responses to incremental infusions of dobutamine in healthy conscious dogs using standardized dobutamine stress echocardiography.
Standardized dobutamine stress echocardiography was performed twice within 24 hours on 8 healthy conscious dogs.
Dobutamine was infused at rates from 12.5 to 42.5 µg/kg/min using incremental step increases of 10 µg/kg/min.
Cardiovascular function was measured via Doppler sphygmomanometry, electrocardiography, and echocardiographic assessment of left ventricular dimensions and systolic performance.
At maximum dosage, dobutamine induced an increase of 20 ± 3% in systolic blood pressure and 109 ± 12% in cardiac index, associated with elevated heart rate and stroke index.
Left ventricular fractional shortening, free wall and septal thickening, ejection fraction, and fiber shortening velocity progressively increased during infusion.
Preejection period and left ventricular ejection time exhibited progressive, significant decreases during stress testing.

Structured PICO

Does dobutamine infusion alter cardiovascular variables during stress echocardiography in healthy dogs?

Population

8 healthy conscious dogs

Intervention

Dobutamine infused at a rate of 12.5 to 42.5 microg/kg/min, using incremental increases of 10 microg/kg/min during standardized dobutamine stress echocardiography (DSE)

Outcome

Response of various cardiovascular variables (systolic blood pressure, cardiac index, heart rate, stroke index, left ventricular size, global ventricular performance, and left ventricular systolic myocardial function)surrogate

Dobutamine stress echocardiography is feasible and safe in healthy conscious dogs, establishing control values for cardiovascular variables.

Discussion

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Implication

Establishes reference values for dobutamine stress echocardiography in healthy dogs; leaves open translation to clinical veterinary populations.

Cite This Study

Entee et al. (1998) studied this question.

synapsesocial.com/papers/6a925d7b23c655f4545ef244 https://doi.org/10.2460/ajvr.1998.59.09.1160

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Implication

Establishes reference values for dobutamine stress echocardiography in healthy dogs; leaves open translation to clinical veterinary populations.