Why the study?
Understanding the key to COVID-19 susceptibility and severity may involve ACE2 variants and isoforms that affect binding affinity with SARS-CoV-2 and influence disease outcomes.
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Design
Review
ACE2 variants may modulate SARS-CoV-2 susceptibility; leaves open whether genotyping informs clinical risk stratification.
Since the identification of its role as the functional receptor for SARS-CoV in 2003 and for SARS-CoV-2 in 2020, ACE2 has been studied in depth to understand COVID-19 susceptibility and severity. ACE2 is a widely expressed protein, and it plays a major regulatory role in the renin-angiotensin-aldosterone System (RAAS). The key to understanding susceptibility and severity may be found in ACE2 variants. Some variants have been shown to affect binding affinity with SARS-CoV-2. In this review, we discuss the role of ACE2 in COVID-19 infection, highlighting the importance of ACE2 isoforms (soluble and membrane-bound) and explore how ACE2 variants may influence an individual's susceptibility to SARS-CoV-2 infection and disease outcome.
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Sodhi et al. (2022) studied this question.
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