What question did this study set out to answer?

To determine whether an endogenous digitalis-like natriuretic factor is present in patients with acromegaly-associated plasma volume expansion and normalizes after successful treatment.

March 5, 1987New England Journal of Medicine

Evidence of an Endogenous Digitalis-like Factor in the Plasma of Patients with Acromegaly

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Authors

GDGilbert DeraySorbonne Université MRM RieuHôpital Cochin MDM A DevynckHôpital Necker-Enfants Malades

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Implication

Comparative study reveals elevated digitalis-like factor activity in active acromegaly, suggesting a physiological role in volume homeostasis.

Key Points

To determine whether an endogenous digitalis-like natriuretic factor is present in patients with acromegaly-associated plasma volume expansion and normalizes after successful treatment.
Assayed plasma extracts from 21 patients with active acromegaly, 11 successfully treated patients, and 27 healthy controls.
Measured plasma extract inhibition of ouabain binding to normal red cell sodium pumps and inhibition of sodium-potassium-ATPase enzymatic activity in normal kidney membrane preparations.
Correlated factor levels with measured plasma volume and evaluated changes following pituitary adenomectomy.
Ouabain-binding inhibition was significantly higher in active acromegaly (mean ± SE: 1.56 ± 0.38) compared to treated patients (0.18 ± 0.05, P < 0.01) and normal controls (0.19 ± 0.03, P < 0.01).
Sodium-potassium-ATPase activity inhibition was elevated in active acromegaly (38.1 ± 6.8%) compared to treated patients (18.4 ± 5.6%, P < 0.05) and controls (21.1 ± 2.7%, P < 0.05).
Plasma volume correlated positively with ouabain-binding inhibition (r = 0.72, P < 0.01, n = 23) and sodium-potassium-ATPase inhibition (r = 0.62, P < 0.01, n = 19), with both measures falling after pituitary adenomectomy.

Cite This Study

Deray et al. (1987) studied this question.

synapsesocial.com/papers/6a925f7b2a0da47949384ab2 https://doi.org/10.1056/nejm198703053161003

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Implication

Comparative study reveals elevated digitalis-like factor activity in active acromegaly, suggesting a physiological role in volume homeostasis.

Evidence of an Endogenous Digitalis-like Factor in the Plasma of Patients with Acromegaly

Discussion

Member takes

Implication

Key Points

Cite This Study

Evidence of an Endogenous Digitalis-like Factor in the Plasma of Patients with Acromegaly

Discussion

Member takes

Implication

Key Points

Cite This Study

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