Why the study?
Does isotonic volume expansion increase plasma levels of atrial natriuretic factor in healthy subjects?
Population
Healthy subjects (n=6 in the saline infusion group, plus a control group)
Comparison
Infusion of 500 ml of 0.9% saline over 45 min vs Control group
Design
Other
Follow-up
75 min postinfusion
Authors
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ANF acts as a circulating hormone responsive to volume expansion; extends prior tissue data but leaves clinical translation open.
Does isotonic volume expansion increase plasma levels of atrial natriuretic factor in healthy subjects?
This study demonstrates that atrial natriuretic factor is a circulating hormone in humans and is secreted in response to isotonic volume expansion.
Yamaji et al. (1985) studied this question.
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