Why the study?
Does the local rigidity of the carotid artery wall differ between atherosclerotic plaques and adjacent healthy tissue in patients with arterial hypertension?
Does the local rigidity of the carotid artery wall differ between atherosclerotic plaques and adjacent healthy tissue in patients with arterial hypertension?
Atherosclerotic plaques in the carotid arteries of hypertensive patients exhibit heterogeneous elastic properties, with greater rigidity at the base compared to the surface, potentially contributing to mechanical instability.
Suggests base rigidity may contribute to plaque vulnerability in hypertension; hypothesis-generating for stiffness-based risk stratification.
Aim: To study the local elastic properties of the arterial wall at the site of atherosclerotic plaque and adjacent areas «healthy» wall of the common carotid artery in patients with arterial hypertension (AH).Materials and methods. The study included 25 patients (3 men, 22 women) with AH 1-2 grad in combination with moderate carotid atherosclerosis and lipid metabolism disorders. All patients underwent conventional ultrasound duplex scanning of the carotid arteries to determine the severity of atherosclerotic carotid arteries and the structure of atherosclerotic plaque. Determination of parameters of the local rigidity - the elasticity of the arterial wall and the atherosclerotic plaque, was carried out on the ultrasound system ALOKA a7. Was scanned and the surroundingarea atherosclerotic plaque sections of the arterial wall in the B/M mode using echo-tracking method.Results. A significant increase in the hardness of the arterial wall in atherosclerotic plaque as in the adventitia and its surface, as compared with the adjacent «healthy» wall of the carotid artery. Atherosclerotic plaque base has significantly greater rigidity and less flexibility than its surface. Conclusion. The formation of atheroma by the action of arterial pulse pressure develops heterogeneity elastic properties carotid wall not only along the artery, but in the atherosclerotic plaque (between its base and the surface). This indicates of different mobility plots artery and plaque and can lead to the formation of the mechanical instability of atherosclerotic plaque in patients with hypertension.
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Vakhovskaya et al. (2014) studied this question.
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