Simple Aziridino Alcohols as Chiral Ligands. Enantioselective Additions of Diethylzinc to N-Diphenylphosphinoylimines

All articles of this category Simple chiral aziridino alcohols 2-5 , easily available from L-serine, L-threonine or L- allo -threonine, have been used as ligands to promote the addition of Et 2 Zn to the diphenylphosphinoylimine 1 (Ar=Ph). Enantioselectivities of up to 94% could be obtained by proper choice of the substituents on the ligand. Up to 90% of the ligand could be recovered during the work-up. The use of ligand 3a as catalyst for the same reaction has also been studied. Diethylzinc - N -diphenylphosphinoylimines - aziridino alcohols - chiral amine - enantioselective addition