Answers are grounded in this paper and cite their sources.
The influence of a sublethal, hypnotic dose of ethanol on metabolism of serotonin was investigated in the mouse. Thirty minutes after intraperitoneal injection of 4.5 g/kg of ethanol, mice were administered 160 mg/kg of serotonin intraperitoneally. At various intervals after the serotonin dose, the whole animal and its excreta were homogenized and analyzed for serotonin, 5-HIAA, and total 5-hydroxyindole compounds. The results clearly demonstrated that alcohol exerted an appreciable inhibitory effect on metabolism of serotonin and depressed its biotransformation via oxidation and conjugation. The enzymatic, toxicologic, and neuropharmacologic implications are discussed.
No takes yet. Share an insight, caveat, or question.
Greg Rosenfeld (1960) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: