Synergistic action of putrefaction amines with histamine was examined by the excised uterus (Magnus method) of a guinea pig and cat blood pressure methods. Each amine was added to the threshold of histamine and the action was observed. Synergistic action was observed in trimethylamine N-oxide, trimethylamine, agmatine (inhibitive in higher concentration), and choline by the Magnus method, and in trimethylamine N-oxide and phosphorylcholine by the cat blood pressure method (cf. Figs. 1-4).
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Makoto Hayashi (1954) studied this question.