Population
gD-null HSV mutant and cell lines
Comparison
Soluble gD ectodomain and mutant constructs vs Virion-bound gD, CD8 substitution…
Design
Preclinical
Authors
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May guide HSV entry inhibitor design; animal data leave open human translation.
The soluble ectodomain of HSV gD contains a membrane-proximal pro-fusion domain that is sufficient to mediate virus entry without being anchored to the virion envelope.
Cocchi et al. (2004) studied this question.
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