Studies of Pancreatic Function in Sjögren's Syndrome

Article1 September 1964Studies of Pancreatic Function in Sjögren's SyndromeL. FREDERICK FENSTER, M.D., W. WATSON BUCHANAN, M.D., LEONARD LASTER, M.D., JOSEPH J. BUNIM, M.D., F.A.C.P.L. FREDERICK FENSTER, M.D., W. WATSON BUCHANAN, M.D., LEONARD LASTER, M.D., JOSEPH J. BUNIM, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-3-498 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONSjögren's syndrome is a chronic, benign, systemic disorder of unknown etiology, involving principally the lacrimal and salivary glands and occasionally other mucus-secreting glands such as the buccal, esophageal, and bronchial mucous glands (1). In about one half of the cases it is associated with rheumatoid arthritis and less frequently with systemic lupus erythematosus, progressive systemic sclerosis (scleroderma), and myopathy or polymyositis (1). The histopathology of this disorder consists of infiltration of the secretory parenchyma of the salivary and lacrimal glands by lymphocytes and plasma cells, atrophy of acinar tissue, and proliferation of ductal epithelial cells (2). These changes give...References1. BUNIM JJ: Heberden oration: a broader spectrum of Sjögren's syndrome and its pathogenetic implications. Ann. Rheum. Dis. 20: 1, 1961. CrossrefMedlineGoogle Scholar2. MORGANCASTLEMAN WSB: Clinicopathologic study of "Mikulicz's disease." Amer. J. Path. 29: 471, 1953. MedlineGoogle Scholar3. CARDELLGURLING BSKJ: Observations on the pathology of Sjögren's syndrome. J. Path. Bact. 68: 137, 1954. CrossrefMedlineGoogle Scholar4. BLOCHBUCHANANWOHLBUNIM KJWWMJJJ: Sjögren's syndrome: a clinical, pathological and serological study of 62 cases. In preparation. Google Scholar5. SUN DC: Normal values for pancreozymin-secretin test. Gastroenterology 44: 602, 1963. CrossrefMedlineGoogle Scholar6. DREILING DA: The technique of the secretin test: normal ranges. J. Mount Sinai Hosp. NY 21: 363, 1955. MedlineGoogle Scholar7. VAN LOONLIKINSSEGER EJMRAJ: Photometric method for blood amylase by use of starch-iodine color. Amer. J. Clin. Path. 22: 1134, 1952. CrossrefMedlineGoogle Scholar8. VAN DE KAMERTEN BOKKEL HUININKWEYERS JHHHA: Rapid method for the determination of fat in feces. J. Biol. Chem. 177: 347, 1949. CrossrefMedlineGoogle Scholar9. Plasma or Serum Vitamin A and Carotene (Carr-Price), in Manual for Nutritional Surveys. The U. S. Interdepartmental Committee on Nutrition for National Defense, May, 1957, pp. 72-74. Google Scholar10. SUNSHAY DCH: Value of combined study of serum enzymes and duodenal contents after secretin in the diagnosis of diseases of the pancreas. Gastroenterology 32: 212, 1957. CrossrefMedlineGoogle Scholar11. GORDONSHANBROM MDE: The systemic manifestations of Sjögren's syndrome: report of glandular function with histologic, bacterial and viral studies. Ann. Intern. Med. 48: 1342, 1958. LinkGoogle Scholar12. CARONELIEBOW FAAA: Acute pancreatic lesions in patients treated with ACTH and adrenal corticoids. New Eng. J. Med. 257: 690, 1957. CrossrefMedlineGoogle Scholar13. PFEFFERHINTON RBJW: Some relationships between adrenal medullary and cortical substances and exocrine function of the pancreas in man. Gastroenterology 31: 746, 1957. CrossrefGoogle Scholar14. DREILINGJANOWITZROLBIN DAHDH: Effect of ACTH and adrenocortical steroids on external pancreatic secretion in man. New Eng. J. Med. 258: 603, 1958. CrossrefMedlineGoogle Scholar15. SIRCUS W: The effect of corticotrophin and corticosteroids on the external secretion of the pancreas in dogs. Gut 2: 338, 1961. CrossrefMedlineGoogle Scholar16. AMROMINDELIMANSHANBROM GDRME: Liver damage after chemotherapy for leukemia and lymphoma. Gastroenterology 42: 401, 1962. CrossrefMedlineGoogle Scholar17. THALMURRAYEGNER APMJW: Isoantibody formation in chronic pancreatic disease. Lancet 1: 1128, 1959. CrossrefMedlineGoogle Scholar18. THALEGNERMURRAY APWMJ: Circulating antibodies in chronic pancreatic disease. Surg. Forum 10: 240, 1959. Google Scholar19. MURRAYTHAL MJAP: The clinical significance of circulating pancreatic antibodies. Ann. Intern. Med. 53: 548, 1960. LinkGoogle Scholar20. METZGAR RS: Immunological studies on the nature of pancreas-specific isoantigens. Fed. Proc. 22: 498, 1963. Google Scholar21. ALLINGTON HV: Dryness of the mouth. Arch. Derm. Syph. (Chicago) 62: 829, 1950. CrossrefGoogle Scholar22. SZANTOFARKASGYULAI LKE: On Sjögren's disease. Rheumatism 13: 60, 1957. MedlineGoogle Scholar23. BUCHERREID UGL: Sjögren's syndrome: report of a fatal case with pulmonary and renal lesions. Brit. J. Dis. Chest 53: 237, 1959. CrossrefMedlineGoogle Scholar24. BAIN GO: The pathology of Mikulicz-Sjögren's disease in relation to disseminated lupus erythematosus: a review of the autopsy findings and presentation of a case. Canad. Med. Ass. J. 82: 143, 1960. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandFrom the Arthritis and Rheumatism Branch and the Gastroenterology Unit of the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md.Dr. Bunim died on July 8, 1964.Requests for reprints should be addressed to Leonard Laster, M.D., Gastroenterology Unit, National Institute of Arthritis and Metabolic Diseases, Bethesda, Md. 20014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySjogren's syndrome: An update on disease pathogenesis, clinical manifestations and treatmentDigestive Involvement in Primary Sjögren's SyndromeGastrointestinal and Hepatic Manifestations of Sjogren SyndromeAfección pancreática en el síndrome de sjögrenPancreatic Disease in Sjögren's Syndrome and IgG4-Related DiseaseSjögren's syndrome and pancreatic affectionThe Second Definition of Sjögren's Syndrome as an Autoimmune DisorderIs Sjögren's syndrome a cause for dry eyes and dry mouth in the elderly?Chapter 7 Digestive Involvement in Primary Sjögren's SyndromeSjögren's Syndrome: Diagnosis and ManagementTHE EFFECTS OF VASCULITIS ON THE GASTROINTESTINAL TRACT AND LIVERMultiple Pancreatic Masses Associated With AutoimmunityPancreatic Exocrine Involvement in Primary Sjogren's SyndromeChronic pancreatitis caused by an autoimmune abnormalityPancreatic involvement in patients with Sjögren's syndrome and primary biliary cirrhosisPancreatic pseudotumor arising in association with Sjögren's syndromeChronic calcifying pancreatitis in rheumatic diseases.Specific cellular immune responses to pancreatic antigen in chronic pancreatitis and Sj�gren's syndromePULMONARY AND GASTROINTESTINAL MANIFESTATIONS OF SJÖGREN'S SYNDROMEPancreatic ductal morphology and function in primary sjögren's syndromePancreatic autoantibodies and pancreatic function in Sjögren's syndromeInterspecies crossreactive antigen of the pancreatic duct cell prepared by monoclonal antibodyPancreatic disease in the autoimmune rheumatic disordersSjögren's syndrome and the gutPancreatic function in Sj�gren's syndromeGastrointestinal and Hepatobiliary Features in Sjögren's SyndromePrimary sjogren syndrome: Clinical and immunopathologic featuresSclerosing cholangitis, chronic pancreatitis, and sjogren's syndrome: A syndrome complexA controlled study of the exocrine pancreatic function in Sjögren's syndrome and rheumatoid arthritisDas Sjögren-Syndrom (Sicca-Syndrom)The Pancreas in Primary Biliary Cirrhosis and Primary Sclerosing CholanitisVanishing tumor of the abdomen in patient with Sj�gren's syndromePankreasgang-Antikörper beim Sjögren-Syndrom und bei chronischer PolyarthritisAntibodies to pancreatic duct cells in Sjogren's syndrome and rheumatoid arthritis.Akute PankreaserkrankungenSjögren's syndromeAbnormalities of Taste and Smell in Sjogren's SyndromeR. I. HENKIN, M.D., N. TALAL, M.D., A. L. LARSON, M.D., C. F. T. MATTERN, M.D.ZUR KENNTNIS DER KERATOCONJUNCTIVITIS SICCA VIIIRecent Advances in the Rheumatic DiseasesEPHRAIM P. ENGLEMAN, M.D., F.A.C.P., MARTIN A. SHEARN, M.D., F.A.C.P.The PancreasGastric studies in sjogren's syndrome. 1 September 1964Volume 61, Issue 3Page: 498-508KeywordsArthritisLymphocytesMetabolic disordersPancreasPancreatitisPlasma cellsPolymyositisRheumatoid arthritisSalivary glandsScleroderma Issue Published: 1 September 1964 PDF DownloadLoading ...