Why the study?
Does esmolol prevent hypertension and tachycardia during emergence from anesthesia and extubation in patients following coronary artery bypass graft surgery?
Does esmolol prevent hypertension and tachycardia during emergence from anesthesia and extubation in patients following coronary artery bypass graft surgery?
Esmolol effectively attenuates the hemodynamic response (hypertension and tachycardia) during extubation following CABG surgery.
Esmolol may be used to blunt extubation-related hemodynamic surges after CABG; extends RCT evidence for short-acting beta-blockade in cardiac surgical recovery.
We have assessed the cardiovascular changes associated with emergence from anaesthesia, reversal of neuromuscular blockade and extubation in a group of 14 patients immediately after coronary artery bypass graft surgery had been completed. Patients were randomly allocated to receive either esmolol 500 micrograms.kg-1 over 1 min followed by 100 micrograms.kg-1.min-1 or placebo starting prior to reversal. Significant hypertension and tachycardia occurred in the placebo group, whilst these changes were prevented by the administration of esmolol.
No takes yet. Share an insight, caveat, or question.
O'Dwyer et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: