Population
Models of hypoxic pulmonary hypertension and pulmonary vasculature exposed to chronic hypoxia
Design
Review
Authors
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Cautions against immediate practice changes in hypoxic pulmonary hypertension; leaves open targeted therapeutic development.
Chronic hypoxia alters pulmonary vasoreactivity through changes in vasoactive factors and direct effects on smooth muscle cells, contributing to the development of hypoxic pulmonary hypertension.
Shimoda et al. (2000) studied this question.
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