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More pieces for the puzzle. The β-methylaspartate-α-decarboxylase (CrpG) from the cryptophycin biosynthetic pathway was cloned, over-expressed, and purified. We found that CrpG decarboxylates (2S,3R)-3-methylaspartic acid to form 3-amino-2(R)-methylpropionic acid, which is subsequently incorporated into Unit C of cryptophycins (see scheme).
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Beck et al. (2007) studied this question.
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